She, The Ultimate Weapon

Shuuji and Chise are third year students at a high school in Hokkaido. The shy Chise is finally confessing to Shuuji, and finally the two of them are starting to exchange diary awkwardly. One day, Shuuji tries to escape from a sudden enemy air raid on Sapporo. While desperately escaping from the air raid, Shuuji sees a scene that he could not forget for his life. He sees Chise, with a huge weapon looking as if it was part of her hand, shooting the enemy fighters down one by one. Apparently, Chise is the ultimate weapon with destructive power which is important for the war. (Source: AniDB)

Neon Genesis Evangelion

In the year 2015, the Angels, huge, tremendously powerful, alien war machines, appear in Tokyo for the second time. The only hope for Mankind's survival lies in the Evangelion, a humanoid fighting machine developed by NERV, a special United Nations agency. Capable of withstanding anything the Angels can dish out, the Evangelion's one drawback lies in the limited number of people able to pilot them. Only a handful of teenagers, all born fourteen years ago, nine months after the Angels first appeared, are able to interface with the Evangelion. One such teenager is Shinji Ikari, whose father heads the NERV team that developed and maintains the Evangelion. Thrust into a maelstrom of battle and events that he does not understand, Shinji is forced to plumb the depths of his own inner resources for the courage and strength to not only fight, but to survive, or risk losing everything. (Source: AniDB) Note: Later releases include edited versions of Episodes 21-24 called the "Director's Cut" with some visual editing and adding extra scenes that appeared in the theatrical recap 'Death'.</i>

H2O: Footprints in the Sand

Takuma Hirose is a blind young male high school student, though the cause for his blindness is undetermined. In order to heal his medical condition, he is sent to live in a village with his uncle. There, he meets several girls, three of which stand out more than any of the others. They are Hayami Kohinata, Hinata Kangura, and Otoha. Otoha temporarily heals his blindness and Hirose uses his sight to help others. He finds out that, for some reason, Hayami Kohinata is hated in the village, and he tries his best to help her out. Meanwhile, many sad secrets unfold in the village...

ef ~ A Tale of Memories

On Christmas Eve, Hiro Hirono's bike is stolen by a girl chasing a thief who stole her purse. He gives chase and finds her unconscious and his bike ruined. The girl, Miyako Miyamura, soon awakes and the two begin to talk. After making sure she is okay, they end up spending Christmas Eve together. Later, Hiro finds out Miyako attends the same school as him and they begin to spend more and more time together, Miyako developing affections for Hiro. Kei Shindou -- Hiro's childhood friend who has long held a crush on him -- begins to become jealous and a love triangle follows. The series also tells the story of Renji Asou. One day, he meets Chihiro Shindou, the twin sister of Kei Shindou, at an abandoned train station. Even though she's very shy, they get along pretty well and begin meeting at the same spot everyday. However, Renji finds out that Chihiro was in a car accident years ago and as a consequence she suffers from a disability: her memory lasts only 13 hours. Nevertheless, after learning that Chihiro's dream is to write a novel, Renji finally decides to help her fulfill her dream while also trying to make her overcome the difficulties imposed by her condition.

ef ~ A Tale of Melodies

In a story set years in the past, Himura Yuu is a studious and diligent young man intent solely on maintaining his top academic position at Otowa Academy. One day, he meets a mysterious girl named Amamiya Yuuko, who, to his surprise, recognizes him. Memories of a distant childhood, memories rather left forgotten...meeting Yuuko again will force Yuu to confront the regrets and sorrows of their collective pasts and presents. In the present, Kuze Shuuichi may seem like a womanizer, but upon closer inspection, is a man who would rather be left alone. Hayama Mizuki, however, is not the type of girl who would let him be, especially after hearing the beautiful sounds of his violin performance. As Mizuki attempts to become closer to him, Kuze attempts to push her away&mdash;the tale of their budding relationship is darkened with undertones of an imminent tragedy.

WorldEnd: What are you doing at the end of the world? Are you busy? Will you save us?

Five hundred years have passed since the humans went extinct at the hands of the fearsome and mysterious ‘Beasts’. The surviving races now make their homes up on floating islands in the sky, out of reach of all but the most mobile of Beasts. Only a small group of young girls, the Leprechauns, can wield the ancient weapons needed to fend off invasions from these creatures. Into the girls’ unstable and fleeting lives, where a call to certain death could come at any moment, enters an unlikely character: a young man who lost everything in his final battle five hundred years ago, the last living human awakened from a long, icy slumber. Unable to fight any longer, Willem becomes the father that the girls never had, caring for and nurturing them even as he struggles to come to terms with his new life, in which he feels the pain of helplessly waiting for his loved ones to return home from battle that his ‘Daughter’ once felt for him so long ago. Together, Willem and the girls gradually come to understand what family means and what is truly worth protecting.

Voices of a Distant Star

It is 2046 when a mysterious alien force begins their annihilation of the human race. Leaving behind the one person she loves, Mikako joins the interstellar battle as a pilot. And so - while Mikako risks her life to save mankind - Noboru waits. At first days, then months, then years for each new message that will let him know whether Mikako is still alive. And, while she barely grows older in the timelessness of space, Noboru ages. The two lovers, worlds apart, desperately strive to remain connected as the gap between them widens at a frightening pace. (Source: Crunchyroll)

DESPAIR OF THE MONSTER

A story about fourteen-year-old alien girl Aoi Hoshino. Her family uses a certain medicine to disguise themselves as humans. For some reason the medicine slowly stops working, but only on Aoi... (Source: Official Website, edited)

Yuki Yuna is a Hero

Yuuna Yuuki is an ordinary second-year middle school student. She gets up in the morning, gets ready for school, goes to classes, participates in club activities, and has fun with her friends. But there is one extraordinary thing about Yuuki — she belongs to the “Brave Hero Club.” What does the Brave Hero Club do? Who is the mysterious being called “Vertex?” Yuuki Yuuna and her friends’ story takes place in Year 300, Era of the Gods. (Source: Ponycan USA)

Elfen Lied

The Diclonius, a mutated homosapien that is said to be selected by God and will eventually become the destruction of mankind, possess two horns on their heads and have a "sixth sense" which gives them telekinetic abilities. Due to this dangerous power, they have been captured and isolated in laboratories by the government. Lucy, a young and psychotic Diclonius, manages to break free of her confines and brutally murders most of the guards in the laboratory where she is being held, only to be shot in the head as she makes her escape. She survives, falling off a cliff into the ocean and manages to drift along to a beach where two teenagers, Kouta and Yuka, discover her. Having lost her memories, she was named after the only thing that she can now say, "Nyuu," and the two allow her to stay at Kouta's home. However, it appears that the psychotic side of Lucy is not dead just yet... (Source: ANN - Revised)